A Lipid Gate for the Peripheral Control of Pain
نویسندگان
چکیده
منابع مشابه
A lipid gate for the peripheral control of pain.
Cells in injured and inflamed tissues produce a number of proalgesic lipid-derived mediators, which excite nociceptive neurons by activating selective G-protein-coupled receptors or ligand-gated ion channels. Recent work has shown that these proalgesic factors are counteracted by a distinct group of lipid molecules that lower nociceptor excitability and attenuate nociception in peripheral tissu...
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15 صفحه اولGate Control Theory of Pain
The gate control theory of pain, put forward by Ronald Melzack (a Canadian psychologist) and Patrick David Wall (a British physician) in 1962, and again in 1965, is the idea that the perception of physical pain is not a direct result of activation of nociceptors, but instead is modulated by interaction between different neurons, both pain-transmitting and non-pain-transmitting. The theory asser...
متن کاملThe gate control theory of pain.
For example, you will probably be aware that there are times when, even though you have pain, you are only dimly aware of it. This may happen when you are really engrossed in doing something interesting or having to face a situation which demands all of your attention. A very good example of this is the stories you might have heard about wounded soldiers who, despite being seriously injured, wi...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3475-14.2014